Renin secretion is controlled by at least four mechanisms that are not mutually exclusive : a renal vascular receptor responds to changes in tension in the afferent arteriolar wall ; a macula densa receptor detects changes in the delivery rate or concentration of nacl in the distal tubule ; circulating angiotensin has a negative feedback effect on renin secretion ; and the sympathetic nervous system stimulates renin secretion via the renal nerve mediated by receptors 肾素的分泌至少受四种互不排斥的机制控制：肾血管受体对向心小动脉壁张力变化的反应；致密斑受体发现远端肾小管内氯化钠传递速率或浓度的变化；循环的血管紧张素对肾素的分泌的负反馈效应；和交感神经系统经由受体介导的肾神经刺激分泌肾素。
